Regie: Anthony Bell
Alpha und Omega erzählt die Geschichte eines etwas naiven Wolfsrüden namens Humphrey und einer reiferen Fähe namens Kate, welche im Jasper-Nationalpark, Kanada, leben. Die beiden sind seit ihrer Kindheit die besten Freunde. Humphrey hat im Rudel einen niederen sozialen Rang (Omega-Wolf), wohingegen Kate als Alpha-Wolf zur Rudelführung gehört. Dennoch sind sie miteinander befreundet.
Justin Long
Humphrey (voice)
Hayden Panettiere
Kate (voice)
Dennis Hopper
Tony (voice)
Danny Glover
Winston (voice)
Larry Miller
Marcel (voice)
Eric Price
Paddy / Mooch (voice)
Vicki Lewis
Eve (voice)
Chris Carmack
Garth (voice)
Kevin Sussman
Shakey (voice)
Brian Donovan
Salty (voice)
Christina Ricci
Lilly (voice)
Elizabeth Tulloch
Sweets (voice)
Christine Lakin
Reba (voice)
Mindy Sterling
Debbie (voice)
Fred Tatasciore
Garn (voice)
Nika Futterman
Porcupine (voice)
Mela Lee
Candy (voice)
Steve Vinovich
Park Ranger (voice)
Aziz Ansari
Thug (voice) (uncredited)
Eric Lopez
Can-do (voice)
Justin Long
Humphrey (voice)
Hayden Panettiere
Kate (voice)
Dennis Hopper
Tony (voice)
Danny Glover
Winston (voice)
Larry Miller
Marcel (voice)
Eric Price
Paddy / Mooch (voice)
Vicki Lewis
Eve (voice)
Chris Carmack
Garth (voice)
Kevin Sussman
Shakey (voice)
Brian Donovan
Salty (voice)
Christina Ricci
Lilly (voice)
Elizabeth Tulloch
Sweets (voice)
Christine Lakin
Reba (voice)
Mindy Sterling
Debbie (voice)
Fred Tatasciore
Garn (voice)
Nika Futterman
Porcupine (voice)
Mela Lee
Candy (voice)
Steve Vinovich
Park Ranger (voice)
Aziz Ansari
Thug (voice) (uncredited)
Eric Lopez
Can-do (voice)
Justin Long
Humphrey (voice)
Hayden Panettiere
Kate (voice)
Dennis Hopper
Tony (voice)
Danny Glover
Winston (voice)
Larry Miller
Marcel (voice)
Eric Price
Paddy / Mooch (voice)
Vicki Lewis
Eve (voice)
Chris Carmack
Garth (voice)
Kevin Sussman
Shakey (voice)
Brian Donovan
Salty (voice)
Christina Ricci
Lilly (voice)
Elizabeth Tulloch
Sweets (voice)
Christine Lakin
Reba (voice)
Mindy Sterling
Debbie (voice)
Fred Tatasciore
Garn (voice)
Nika Futterman
Porcupine (voice)
Mela Lee
Candy (voice)
Steve Vinovich
Park Ranger (voice)
Aziz Ansari
Thug (voice) (uncredited)
Eric Lopez
Can-do (voice)