Réalisation: Roy William Neill
Pendant la Seconde Guerre mondiale, Sherlock Holmes favorise la fuite du docteur Franz Tobel, inventeur d'un viseur novateur, et le protège des nazis qui le recherchent. Le docteur part se réfugier à Londres, et inquiet de la portée de son invention, décide de confier à quatre scientifiques connus par lui seul, une partie de son œuvre et remet à sa fiancée Charlotte une codification des noms de ces quatre hommes avant de disparaître. Holmes se met à sa recherche et très vite comprend que l’immonde Moriarty est sur les traces des quatre scientifiques.
Basil Rathbone
Sherlock Holmes
Nigel Bruce
Doctor Watson
Lionel Atwill
Professor Moriarty
William Post Jr.
Dr. Franz Tobel
Kaaren Verne
Charlotte Eberli
Dennis Hoey
Inspector Lestrade
Holmes Herbert
Sir Reginald
Mary Gordon
Mrs. Hudson
Harry Cording
Jack Brady (uncredited)
Harold De Becker
Peg Leg (uncredited)
Paul Fix
Mueller (uncredited)
Henry Victor
Professor Frederic Hoffner (uncredited)
John Burton
RAF Officer (uncredited)
Paul Bryar
Swiss Waiter (uncredited)
Whit Bissell
London Bobbie (uncredited)
Rudolph Anders
Braun (uncredited)
Colin Kenny
Scotland Yard Detective (uncredited)
George Burr Macannan
Gottfried (uncredited)
Harry Woods
Kurt (uncredited)
Basil Rathbone
Sherlock Holmes
Nigel Bruce
Doctor Watson
Lionel Atwill
Professor Moriarty
William Post Jr.
Dr. Franz Tobel
Kaaren Verne
Charlotte Eberli
Dennis Hoey
Inspector Lestrade
Holmes Herbert
Sir Reginald
Mary Gordon
Mrs. Hudson
Harry Cording
Jack Brady (uncredited)
Harold De Becker
Peg Leg (uncredited)
Paul Fix
Mueller (uncredited)
Henry Victor
Professor Frederic Hoffner (uncredited)
John Burton
RAF Officer (uncredited)
Paul Bryar
Swiss Waiter (uncredited)
Whit Bissell
London Bobbie (uncredited)
Rudolph Anders
Braun (uncredited)
Colin Kenny
Scotland Yard Detective (uncredited)
George Burr Macannan
Gottfried (uncredited)
Harry Woods
Kurt (uncredited)
Basil Rathbone
Sherlock Holmes
Nigel Bruce
Doctor Watson
Lionel Atwill
Professor Moriarty
William Post Jr.
Dr. Franz Tobel
Kaaren Verne
Charlotte Eberli
Dennis Hoey
Inspector Lestrade
Holmes Herbert
Sir Reginald
Mary Gordon
Mrs. Hudson
Harry Cording
Jack Brady (uncredited)
Harold De Becker
Peg Leg (uncredited)
Paul Fix
Mueller (uncredited)
Henry Victor
Professor Frederic Hoffner (uncredited)
John Burton
RAF Officer (uncredited)
Paul Bryar
Swiss Waiter (uncredited)
Whit Bissell
London Bobbie (uncredited)
Rudolph Anders
Braun (uncredited)
Colin Kenny
Scotland Yard Detective (uncredited)
George Burr Macannan
Gottfried (uncredited)
Harry Woods
Kurt (uncredited)