Réalisation: Alfred L. Werker
Le film commence sur les marches de Old Bailey, où Moriarty vient d'être acquitté d'une accusation de meurtre en raison d'un manque de preuves. Holmes lui fait cette remarque : « Vous avez un cerveau magnifique, Moriarty. Je l'admire. Je l'admire tellement que je tiens à le présenter, marinée dans l'alcool, à la Société Médicale de Londres ». « Cela ferait une exposition impressionnante », répond Moriarty.
Basil Rathbone
Sherlock Holmes
Nigel Bruce
Dr. Watson
Ida Lupino
Ann Brandon
Alan Marshal
Jerrold Hunter
Terry Kilburn
Billy
George Zucco
Professor Moriarty
Henry Stephenson
Sir Ronald Ramsgate
E. E. Clive
Inspector Bristol
Arthur Hohl
Henchman Bassick
May Beatty
Mrs. Jameson, Brandon Housekeeper
Peter Willes
Lloyd Brandon
Mary Gordon
Mrs. Hudson
Holmes Herbert
Justice of the Court
George Regas
Henchman Mateo
Mary Forbes
Lady Conyngham
Frank Dawson
Dawes, Moriarty's servant
William Austin
Inquisitive Stranger
Anthony Kemble-Cooper
Tony Conyngham
Leonard Mudie
Barrows - Moriarty's Attorney (uncredited)
Robert Nobel
Foreman of the Jury (uncredited)
Basil Rathbone
Sherlock Holmes
Nigel Bruce
Dr. Watson
Ida Lupino
Ann Brandon
Alan Marshal
Jerrold Hunter
Terry Kilburn
Billy
George Zucco
Professor Moriarty
Henry Stephenson
Sir Ronald Ramsgate
E. E. Clive
Inspector Bristol
Arthur Hohl
Henchman Bassick
May Beatty
Mrs. Jameson, Brandon Housekeeper
Peter Willes
Lloyd Brandon
Mary Gordon
Mrs. Hudson
Holmes Herbert
Justice of the Court
George Regas
Henchman Mateo
Mary Forbes
Lady Conyngham
Frank Dawson
Dawes, Moriarty's servant
William Austin
Inquisitive Stranger
Anthony Kemble-Cooper
Tony Conyngham
Leonard Mudie
Barrows - Moriarty's Attorney (uncredited)
Robert Nobel
Foreman of the Jury (uncredited)
Basil Rathbone
Sherlock Holmes
Nigel Bruce
Dr. Watson
Ida Lupino
Ann Brandon
Alan Marshal
Jerrold Hunter
Terry Kilburn
Billy
George Zucco
Professor Moriarty
Henry Stephenson
Sir Ronald Ramsgate
E. E. Clive
Inspector Bristol
Arthur Hohl
Henchman Bassick
May Beatty
Mrs. Jameson, Brandon Housekeeper
Peter Willes
Lloyd Brandon
Mary Gordon
Mrs. Hudson
Holmes Herbert
Justice of the Court
George Regas
Henchman Mateo
Mary Forbes
Lady Conyngham
Frank Dawson
Dawes, Moriarty's servant
William Austin
Inquisitive Stranger
Anthony Kemble-Cooper
Tony Conyngham
Leonard Mudie
Barrows - Moriarty's Attorney (uncredited)
Robert Nobel
Foreman of the Jury (uncredited)