Dirección: Betty Thomas
Un cirujano que posee la facultad de entender el lenguaje de los animales intentará solucionar sus problemas personales y los de los más diversos animales que acuden a su consulta.
Eddie Murphy
Dr. John Dolittle
Ossie Davis
Archer Dolittle
Oliver Platt
Dr. Mark Weller
Peter Boyle
Calloway
Richard Schiff
Dr. Gene Reiss
Kristen Wilson
Lisa
Jeffrey Tambor
Dr. Fish
Kyla Pratt
Maya
Raven-Symoné
Charisse
Steven Gilborn
Dr. Litvack
Erik Dellums
Jeremy
June Christopher
Diane
Cherie Franklin
Mrs. Parkus
Norm Macdonald
Lucky (voice)
Chris Rock
Rodney (voice)
Albert Brooks
Tiger (voice)
Jenna Elfman
Owl (Voice)
Reni Santoni
Rat #1 (Voice)
John Leguizamo
Rat #2 (Voice)
Julie Kavner
Female Pigeon (voice)
Eddie Murphy
Dr. John Dolittle
Ossie Davis
Archer Dolittle
Oliver Platt
Dr. Mark Weller
Peter Boyle
Calloway
Richard Schiff
Dr. Gene Reiss
Kristen Wilson
Lisa
Jeffrey Tambor
Dr. Fish
Kyla Pratt
Maya
Raven-Symoné
Charisse
Steven Gilborn
Dr. Litvack
Erik Dellums
Jeremy
June Christopher
Diane
Cherie Franklin
Mrs. Parkus
Norm Macdonald
Lucky (voice)
Chris Rock
Rodney (voice)
Albert Brooks
Tiger (voice)
Jenna Elfman
Owl (Voice)
Reni Santoni
Rat #1 (Voice)
John Leguizamo
Rat #2 (Voice)
Julie Kavner
Female Pigeon (voice)
Eddie Murphy
Dr. John Dolittle
Ossie Davis
Archer Dolittle
Oliver Platt
Dr. Mark Weller
Peter Boyle
Calloway
Richard Schiff
Dr. Gene Reiss
Kristen Wilson
Lisa
Jeffrey Tambor
Dr. Fish
Kyla Pratt
Maya
Raven-Symoné
Charisse
Steven Gilborn
Dr. Litvack
Erik Dellums
Jeremy
June Christopher
Diane
Cherie Franklin
Mrs. Parkus
Norm Macdonald
Lucky (voice)
Chris Rock
Rodney (voice)
Albert Brooks
Tiger (voice)
Jenna Elfman
Owl (Voice)
Reni Santoni
Rat #1 (Voice)
John Leguizamo
Rat #2 (Voice)
Julie Kavner
Female Pigeon (voice)