Dirección: Robert C. Ramirez
Clifford pasará multitud de aventuras en compañía de Cleo y T-Bone, haciendo amigos por todos los sitios por los que pasan.
John Ritter
Clifford the Big Red Dog (voice)
Wayne Brady
Shackelford (voice)
Grey DeLisle
Emily Elizabeth (voice)
Jenna Elfman
Dorothy (voice)
John Goodman
George Wolfsbottom (voice)
Jess Harnell
Dirk (voice)
Kel Mitchell
T-Bone (voice)
Judge Reinhold
Larry (voice)
Kath Soucie
Jetta / Madison (voice)
Cree Summer
Cleo (voice)
Wilmer Valderrama
Rodrigo (voice)
Earl Boen
Mr. Bleakman (voice)
Cam Clarke
Mr. Mark Howard / Marcus (voice)
Teresa Ganzel
Liza (voice)
Ernie Hudson
P.T. (voice)
Nick Jameson
Sheriff Lewis (voice)
Oren Williams
Charley (voice)
