Director: Bobby Farrelly
A white blood cell policeman, with the help of a cold pill, must stop a deadly virus from destroying the human they live in, Frank.
Chris Rock
Osmosis Jones (voice)
Laurence Fishburne
Thrax (voice)
David Hyde Pierce
Drix (voice)
Brandy Norwood
Leah (voice)
Elena Franklin
Shane Detorre
Bill Murray
Frank Detorre
William Shatner
Mayor Phlegmming (voice)
Ron Howard
Tom Colonic (voice)
Kid Rock
Kidney Rock (voice)
Molly Shannon
Mrs. Boyd
Chris Elliott
Bob
Jonathan Adams
Officer Tom (voice)
Carlos Alazraqui
Spanish Germ (voice)
Keith Anthony
Additional Character Voices (voice)
Eddie Barth
Conductor (voice)
Sally Brooks
Additional Character Voices (voice)
Rodger Bumpass
Joe Cramp / Announcer for Nerve News Network (voice)
Michael Carven
Additional Character Voices (voice)
Paul Christie
Dan Matter / Germ (voice)
Janis Dardaris
Additional Character Voices (voice)
